Enhancement of solubility of dexibuprofen applying mixed hydrotropic solubilization technique
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Formulation and Evaluation of Aceclofenac Injection Made by Mixed Hydrotropic Solubilization Technique
Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that exhibits analgesic, antipyretic and anti-inflammatory activities. It is practically insoluble in water. The effect of hydrotropes such as urea and sodium citrate and blends (urea + sodium citrate) on the solubility of aceclofenac was investigated. The enhancement in the solubility of aceclofenac was more than 5 and 25 folds in 3...
متن کاملFormulation and Evaluation of Aceclofenac Injection Made by Mixed Hydrotropic Solubilization Technique
Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that exhibits analgesic, antipyretic and anti-inflammatory activities. It is practically insoluble in water. The effect of hydrotropes such as urea and sodium citrate and blends (urea + sodium citrate) on the solubility of aceclofenac was investigated. The enhancement in the solubility of aceclofenac was more than 5 and 25 folds in 3...
متن کاملFormulation and Evaluation of Aceclofenac Injection Made by Mixed Hydrotropic Solubilization Technique
Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that exhibits analgesic, antipyretic and anti-inflammatory activities. It is practically insoluble in water. The effect of hydrotropes such as urea and sodium citrate and blends (urea + sodium citrate) on the solubility of aceclofenac was investigated. The enhancement in the solubility of aceclofenac was more than 5 and 25 folds in 3...
متن کاملformulation and evaluation of aceclofenac injection made by mixed hydrotropic solubilization technique
aceclofenac is a non-steroidal anti-inflammatory drug (nsaid) that exhibits analgesic, antipyretic and anti-inflammatory activities. it is practically insoluble in water. the effect of hydrotropes such as urea and sodium citrate and blends (urea + sodium citrate) on the solubility of aceclofenac was investigated. the enhancement in the solubility of aceclofenac was more than 5 and 25 folds in 3...
متن کاملA Review on Solubility Enhancement Using Hydrotropic Phenomena
Solubilization of poorly water-soluble drugs has been a very important issue in screening studies of new chemical entities as well as formulation research. Various techniques are employed to enhance the aqueous solubility of poorly water-soluble drugs and hydrotropic solubilisation is one of them. A hydrotrope is a compound that solubilises hydrophobic compounds in aqueous solution. The problem...
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ژورنال
عنوان ژورنال: Drug Discoveries & Therapeutics
سال: 2014
ISSN: 1881-7831
DOI: 10.5582/ddt.2014.01019